学术2015316他汀类药物的负面

12月1日《欧洲心脏杂志》在线发表一项研究结果显示，有关他汀类药物的负面新闻或与早期停药相关，并可能因此增加心梗及心血管疾病（CVD）死亡危险。

该研究观察了丹麦近67.5万年龄≥40岁、于-年间接受他汀治疗的人群。研究者发现在此期间丹麦的报纸、杂志、广播、电视、网络及通讯社报道了条与他汀相关的新闻，并评估这些新闻对停药的影响。

结果显示，他汀使用率从年的1%增至年的11%，但早期停药率从的6%增至的18%。研究者发现，他汀负面新闻曝光与早期停药相关，并可以解释2%所有心梗以及1%所有与早期停药相关的CVD死亡的原因。尽管还不能确定他汀的负面新闻是否可引起早期停药，但该研究提示有这种可能性。虽然这种相关性研究不能证明其因果关系，但研究数据表明，早期停药可导致不必要的心梗和心血管死亡。

（英文原文）NegativeStatinNewsMaybeAssociatedWithEarlyDiscontinuation,CVDMortality

Negativestatin-relatednewsstoriesmaybeassociatedwithearlystatindiscontinuation,andconsequentlymayincreasetheriskofmyocardialinfarctionandcardiovasculardiseasemortality,accordingtoastudypublishedDec.1inEuropeanHeartJournal.

Thestudylookedat,Danishindividualsages40orolderwhowereusingstatinsfromto.Theauthorsidentified1,statin-relatednewsstoriesfromJanuaryandonwardsinDanishnewspapers,magazines,radio,television,websitesandnewsagenciesandassessedtheeffectonstatindiscontinuation.

Resultsshowedthatindividualsonstatinsincreasedfrom1percentinto11percentin,howeverearlystatindiscontinuationincreasedfrom6percentinto18percentin.

“Wefoundthatexposuretonegativenewsstoriesaboutstatinswaslinkedtostoppingstatinsearlyandexplainedtwopercentofallheartattacksandonepercentofalldeathsfromcardiovasculardiseaseassociatedwithearlydiscontinuationofstatins,”saidB?rgeNordestgaard,MD,DMSc,chiefphysicianatCopenhagenUniversityHospitalinDenmarkandaco-authorofthestudy.

“Althoughwecannotsayforsurethatstatin-relatednegativenewsstoriescausetheearlydiscontinuationofstatins,ourfindingssuggestthatthisislikely.Andalthoughthistypeofassociationresearchcannotprovecausality,ourdatasuggestthatearlydiscontinuationofstatinsleadstounnecessaryheartattacksanddeathsfromcardiovasculardisease,”headds.

Theauthorsconcludethatmovingforward,theirfindings“suggestaneedforprotocolsaimedatincreasingearlyadherencetostaintherapy.”

来源：ACCNewsStory（December1，）

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